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What Is Medication Assisted Treatment?

In 2025, nearly 75% of all fatal drug overdoses in the U.S. were caused by opioids, a sobering reality that can make hope feel out of reach. If you or someone you love is struggling, you’re not alone in feeling overwhelmed by the weight of these odds. But recovery from alcohol or opioid use disorder doesn’t have to rest on willpower alone; there’s a proven, medical way forward with medication assisted treatment that can bring real relief and safety, even when things seem impossible.

medication assisted treatment
medication assisted treatment
Key takeaways
  • Medication-Assisted Treatment, or MAT, is an evidence-based approach combining FDA-approved medications with counseling and therapy.

  • MAT is the gold standard of care for opioid use disorder, addressing both the physical and psychological sides of addiction.

  • Medications like Buprenorphine, Methadone, and Naltrexone normalize brain chemistry and reduce withdrawal and cravings.

  • The most important benefit of MAT is that it saves lives, significantly reducing the odds of a fatal overdose.

  • The myth that MAT substitutes one addiction for another confuses physical dependence with the disease of addiction.

What Is Medication Assisted Treatment?

Medication-assisted treatment, often called MAT, is an evidence-based approach that combines FDA-approved medications with counseling and therapy to treat substance use disorder. It’s not about swapping one drug for another; it’s a comprehensive, “whole-patient” method that addresses both the physical and psychological sides of addiction. Think of it as stabilizing the body so the mind has a real chance to heal. The medications help manage withdrawal symptoms and reduce cravings, which creates the stability needed to dig into the root causes of addiction through therapy.

Far from being a lesser option, MAT is considered the gold standard of care for opioid use disorder (OUD). It provides a safe, controlled way to manage the biological aspects of addiction, allowing you to focus on developing the coping skills needed for lasting recovery. At its core, this approach combines medical science with personalized, compassionate care to give you the best possible foundation for building a new life.

What Are The Medications Used In MAT?

In medication-assisted treatment, several FDA-approved medications are used to help treat opioid and alcohol use disorders. These aren’t one-size-fits-all solutions. The right medication for you is a clinical decision that you and your healthcare provider will make together, based on your specific health needs, the substance used, and your recovery goals. The goal is to find the option that gives you the best support for a successful recovery journey.

Medications For Opioid Use Disorder

For opioid use disorder, the medications work by interacting with the same receptors in the brain that opioids do, but in a much safer and more controlled way. This helps to normalize brain chemistry without producing a high for those struggling with opioid use disorder.

  • Buprenorphine: This is a partial opioid agonist. It binds to and partially activates opioid receptors, which is enough to ease withdrawal symptoms and reduce cravings. Because it only partially activates them, there’s a “ceiling effect,” making it much harder to participate in opioid misuse and lowering the risk of overdose. It’s often combined with naloxone in a brand-name medication called Suboxone.
  • Methadone: As a full opioid agonist, methadone activates opioid receptors more completely than buprenorphine. It works by reducing cravings and withdrawal symptoms. It has been used safely for decades in those with opioid use disorder and is dispensed through specialized clinics, ensuring controlled, daily dosing.
  • Naltrexone: Unlike the other two, naltrexone is an opioid antagonist. This means it completely blocks the euphoric and sedative effects of opioids. If a person taking naltrexone uses opioids, they won’t feel a high. This can be a powerful tool for preventing relapse, especially for those who have already completed detox. It is available as a daily pill or a monthly injection (Vivitrol).

Medications for Alcohol Use Disorder

For those with an alcohol use disorder (AUD), which affects millions of people in the U.S. as of 2019, medications work by either reducing cravings or creating an unpleasant physical reaction to drinking.

  1. Naltrexone: Just as with opioids, naltrexone can help people with AUD by reducing the pleasurable effects of drinking and curbing cravings. It helps break the cycle of associating alcohol with reward.
  2. Acamprosate: This medication is thought to work by restoring the chemical balance in the brain that gets disrupted by long-term heavy drinking. It helps reduce the persistent, unpleasant feelings that can lead to relapse, like anxiety and insomnia.
  3. Disulfiram: This medication works differently. It causes a severe negative reaction when someone drinks alcohol, including symptoms like nausea, vomiting, and flushing. It’s used as a deterrent to help people who are committed to stopping drinking avoid impulsive use.

What Are The Benefits Of MAT?

The most important benefit of medication-assisted treatment access is that it saves lives. The evidence is clear and overwhelming. According to a study of Medicare beneficiaries, buprenorphine reduced the odds of a fatal overdose by 52%, while methadone reduced the odds by 58%. By managing withdrawal and cravings, MAT provides the stability people need to fully engage in their recovery. This foundation allows individuals to focus on therapy, rebuild relationships, and reclaim their lives from addiction.

Other proven benefits include increased treatment retention rates, a decrease in illicit opioid use, and improved ability to find and maintain employment. For pregnant women with a substance use disorder, MAT can improve birth outcomes. Ultimately, MAT gives people the chance to move beyond the daily struggle of addiction and work toward long-term well-being, similar to the stability found in residential treatment programs.

Doesn’t Using These Medications Just Substitute One Addiction For Another?

That’s a common concern, but it comes from a deep misunderstanding of how these medications work. The idea that MAT just trades one addiction for another is a myth rooted in stigma. There’s a crucial difference between physical dependence and addiction. Physical dependence is a normal physiological response when your body gets used to a substance. If you stop suddenly, you’ll experience withdrawal.

Addiction, on the other hand, is a compulsive, uncontrollable use of a substance despite harmful consequences. It’s a disease of the brain’s reward system. Think of it like a person with diabetes who needs insulin. They are dependent on insulin to function and stay healthy, but they aren’t addicted to it. MAT medications work similarly for someone with a substance use disorder. When taken as prescribed, these medications normalize brain chemistry and relieve withdrawal symptoms without producing a “high.”

This allows a person to stop the destructive patterns of addiction and focus on their recovery, healing, and life. Understanding the difference between addiction and dependence helps clarify why MAT is a legitimate medical treatment, not a substitute for the problem.

Frequently Asked Questions

Does Insurance Cover MAT Treatments?

Yes, most insurance plans provide coverage for Medication-Assisted Treatment (MAT). Federal laws, including the Mental Health Parity and Addiction Equity Act, require many health plans to cover treatment for substance use disorder just as they would any other medical condition.

This includes Medicaid, which covers MAT in every state. It’s always best to check the specifics of your plan, but a quality treatment center can help you quickly verify your insurance benefits to see exactly what is covered.

How Long Does MAT Last?

There is no set timeline for MAT because the treatment is customized for each person’s unique journey. For some patients, it may be a short-term solution to get through withdrawal and early recovery safely. For others, it can serve as a long-term maintenance therapy, much like taking medication for any other chronic health condition.

The right duration is a medical decision you and your provider will make together, based on your progress and overall well-being. The main goal is to provide support for as long as it helps you thrive.

What Are the Components of MAT?

Medication-assisted treatment is a “whole-patient” approach that combines two essential components. The first is FDA-approved medication, such as buprenorphine or naltrexone, which works to normalize brain chemistry, relieve cravings, and manage withdrawal symptoms without providing a high.

The second critical component is counseling and behavioral therapy. This part of the treatment helps you address the psychological aspects of addiction, develop healthy coping skills, and build a strong foundation for a lasting recovery.

Why Are Efforts To Increase Access To MAT Important?

Increasing access to MAT is incredibly important because it is a life-saving medical treatment. When people with opioid use disorder (OUD) can access these medications and therapies, their risk of a fatal overdose drops significantly. It is one of the most effective strategies we have to combat the opioid crisis.

Broader access also means more people can stay in treatment longer, stop using illicit substances, and rebuild their lives. This strengthens families and communities by helping people return to work and wellness.

Finding Medication Assisted Treatment Near You

Finding the right MAT provider can feel like a big step, but there are excellent resources available to guide you. Medication-assisted treatment is a safe, effective, and evidence-based approach that can be a vital part of your recovery. It’s a path that offers hope and saves lives, allowing you to build a stable foundation for a healthier future.

Remember, seeking help is a sign of incredible strength. If you’re ready to take the next step with medication assisted treatment for alcohol or opioid use disorder, our team at pH Wellness is here to help you navigate your options with compassion and expertise. Give us a call at (888) 707-3880 or contact us online for a confidential conversation about how we can support your journey to recovery.

Sources

  1. Substance Abuse and Mental Health Services Administration. (August 25, 2025). Medications for Substance Use Disorders. SAMHSA.
  2. Food and Drug Administration. (December 26, 2024). Information about Medications for Opioid Use Disorder (MOUD). FDA.
  3. National Institute on Alcohol Abuse and Alcoholism. (January 1, 2025). Medications Development Program. NIAAA.
  4. National Institute on Drug Abuse. (April 10, 2025). Drugs A to Z. NIDA.
  5. Centers for Disease Control and Prevention. (June 27, 2024). Treatment for Opioid Use Disorder: Population Estimates. CDC.
  6. Centers for Disease Control and Prevention. April 15, 2025. Medication-Assisted Treatment for Opioid Use Disorder. CDC.
  7. Substance Abuse and Mental Health Services Administration Library. (January 11, 2025). TIP 63: Medications for Opioid Use Disorder. SAMHSA.
  8. National Center for Biotechnology Information. (March 30, 2019). The Effectiveness of Medication-Based Treatment for Opioid Use Disorder. NCBI.
  9. National Center for Biotechnology Information. (June 15, 2020). Effects of Medication-Assisted Treatment (MAT) for Opioid Use Disorder on Functional Outcomes. PMC.
  10. Centers for Medicare & Medicaid Services. (June 17, 2024). Federal Study Examines Care Following Nonfatal Overdose Among Medicare Beneficiaries. CMS.
  11. National Institute on Drug Abuse. (August 21, 2024). Drug Overdose Deaths: Facts and Figures. NIDA.
  12. National Center for Biotechnology Information. (November 9, 2021). Drug dependence is not addiction—and it matters. PMC.
  13. National Cancer Institute. (February 2, 2011). Definition of physical dependence. NCI.
  14. Substance Abuse and Mental Health Services Administration Library. (November 30, 2024). TIP 41 Substance Abuse Treatment: Group Therapy. SAMHSA.
  15. National Center for Biotechnology Information. (November 18, 2016). HEALTH CARE SYSTEMS AND SUBSTANCE USE DISORDERS. NCBI.
  16. National Center for Biotechnology Information. (September 19, 2025). Chapter 6—From Preparation to Action: Initiating Change. NCBI.
  17. Substance Abuse and Mental Health Services Administration Library. (January 11, 2025). TIP 35 Enhancing Motivation for Change in Substance Use Disorder Treatment. SAMHSA.
  18. Centers for Disease Control and Prevention. (June 9, 2025). Public Health Considerations for Strategies and Partnerships. CDC.
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MEDICAL REVIEWER

DR. DAVID YOON, MD MPH
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